Engineered pumping cardiac chambers are a promising technology to study the effects of hemodynamic loads in cardiac performance, in healthy and diseased conditions.

Using a sacrificial moulding approach, we developed a miniature human cardiac chamber that recapitulates the pumping function of the heart.

In this project, we aim to perform a functional and biomechanical characterization of the pumping chambers under static and dynamic load conditioning.  This will provide the basis for accurate disease models using clinically-relevant pressure-volume readouts.