Automated and Multiplexed Organs-on-Chips

Automated, multiplexed cell culturing chips with high spatiotemporal resolution are essential for multiparameter screening and studying response kinetics. Here at AST we are developing highly multiplexed microfluidic chips with integrated valves for programmable cell culture medium exchange and stimulation factor exposure.

Open-TOP (Translational Organ-on-Chip Platform)

The Translational Organ-on-chip Platform (TOP) aims to bridge the gap between organ-on-chip developers and end-users by connecting microfluidic building blocks, such as organs-on-chips and sensors, on fluidic circuit boards in an open, standardized manner. The use of a common, standardized platform in the form of STARTER facilitates collaboration and chip transfer between partners from different labs to achieve higher level (multi-) organ-on-chip systems. STARTER can be used for a wide range of applications, such as parallelized cell culturing, automated medium recirculation and in-line sensing.

Researchers

PhD Candidate

Postdoc

Full Professor

Multiplex micro-engineered patient-specific tissues array for artificial intelligence disease prediction

This project will focus on developing a microfluidic array of micro-engineered heart tissues (µEHT) that combine with artificial intelligence (AI) software, aims to predict disease developments in patients. The microfluidic networks will allow users to control the perfusions of each µEHT. Besides, we will assess the effect of cytokines and different drug compounds on patient-specific µEHT.  This platform will revolutionize not only research methods in academia, but also for clinical test in hospitals and drug development in industries.

Grant
Digipredict

Researchers

PhD Candidate

Marcelo C. Ribeiro

Guest Researcher

Full Professor