Automated and Multiplexed Organs-on-Chips
Automated, multiplexed cell culturing chips with high spatiotemporal resolution are essential for multiparameter screening and studying response kinetics. Here at AST we are developing highly multiplexed microfluidic chips with integrated valves for programmable cell culture medium exchange and stimulation factor exposure.
Open-TOP (Translational Organ-on-Chip Platform)
The Translational Organ-on-chip Platform (TOP) aims to bridge the gap between organ-on-chip developers and end-users by connecting microfluidic building blocks, such as organs-on-chips and sensors, on fluidic circuit boards in an open, standardized manner. The use of a common, standardized platform in the form of STARTER facilitates collaboration and chip transfer between partners from different labs to achieve higher level (multi-) organ-on-chip systems. STARTER can be used for a wide range of applications, such as parallelized cell culturing, automated medium recirculation and in-line sensing.
Automated fluid control of micro EHTs on TOP
Previously, our lab published a four cell type micro engineered heart tissue.
µEHTs consist of 50-60k cells and are made of cardiomyocytes, fibroblasts, smooth muscle cells, and endothelial cells. To advance this chip, we will adopt the design and make it suitable for the translational organ-on-chip platform (TOP) developed within our lab. This enables automated fluid control and potentially more standardized read-outs.
µEHTs on TOP will enable new avenues for research.
Funding
ZonMw Open Competition and HH TKI OoC call
Researchers
PhD Candidate
PhD Candidate
Full Professor