Publications

Since
2000
Scientific output
0

2025

Blood-perfused vessels-on-chip for disease modelling and precision medicine (2025) [Thesis › PhD Thesis – Research UT, graduation UT]. University of Twente. Weener, H. J. https://doi.org/10.3990/1.9789036567107
 
Retina-on-chip with local oxygen sensing (2025) [Thesis › PhD Thesis – Research UT, graduation UT]. University of Twente. Gensheimer, T. https://doi.org/10.3990/1.9789036567084
 
Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19 (2025) Lab on a chip, 25(7), 1787-1800. Weener, H. J., van Haaps, T. F., van Helden, R. W. J., Albers, H. J., Haverkate, R., Middelkamp, H. H. T., Ridderikhof, M. L., van Mens, T. E., van den Berg, A., Mummery, C. L., Orlova, V. V., Middeldorp, S., van Es, N. & van der Meer, A. D. https://doi.org/10.1039/d4lc00848k
 
 
Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment (2025) Stem cell reports, 20(3). Article 102422. Snabel, R. R., Cofiño-Fabrés, C., Baltissen, M., Schwach, V., Passier, R. & Veenstra, G. J. C. https://doi.org/10.1016/j.stemcr.2025.102422
 
FORCETRACKER: A versatile tool for standardized assessment of tissue contractile properties in 3D Heart-on-Chip platforms (2025) PLoS ONE, 20(2 February). Article e0314985. Rivera-Arbeláez, J. M., Dostanić, M., Windt, L. M., Stein, J. M., Cofiño-Fabres, C., Boonen, T., Wiendels, M., Van Den Berg, A., Segerink, L. I., Mummery, C. L., Sarro, P. M., Van Meer, B. J., Ribeiro, M. C., Mastrangeli, M. & Passier, R. https://doi.org/10.1371/journal.pone.0314985
 
Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technology (2025) Lab on a chip, 25(5), 996-1014. Gensheimer, T., Veerman, D., van Oosten, E. M., Segerink, L., Garanto, A. & van der Meer, A. D. https://doi.org/10.1039/d4lc00823e

 

2024

 
Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept (2024) Journal of Immunotoxicology, 21(suppl. 1), S13-S28. Alb, M., Reiche, K., Rade, M., Sewald, K., Loskill, P., Cipriano, M., Maulana, T. I., van der Meer, A. D., Weener, H. J., Clerbaux, L. A., Fogal, B., Patel, N., Adkins, K., Lund, E., Perkins, E., Cooper, C., van den Brulle, J., Morgan, H., Rubic-Schneider, T., … Hudecek, M. https://doi.org/10.1080/1547691X.2024.2345158
 
Biopurification using non-growing microorganisms to improve plant protein ingredients (2024) npj Science of Food, 8(1). Article 48. Nugroho, A. D. W., van Schalkwijk, S., Cebeci, S., Jacobs, S., Wesselink, W., Staring, G., Goerdayal, S., Prodan, A., Stijnman, A., Teuling, E., Broersen, K. & Bachmann, H. https://doi.org/10.1038/s41538-024-00290-x
 
Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels (2024) Small, 20(46). Article 2403272. Husch, J. F. A., Araújo-Gomes, N., Willemen, N. G. A., Cofiño-Fabrés, C., van Creij, N., Passier, R., Leijten, J. & van den Beucken, J. J. J. P. https://doi.org/10.1002/smll.202403272
 
The Effects Of In Vitro Exercise Of Engineered Heart Tissues On Cardiac Injury And Function: 721 (2024) Medicine and science in sports and exercise, 56(10S), 247-247. Luiken, T. T. J., Cofiño-Fabres, C., Rivera-Arbeláez, J. M., Snippert, D., Denessen, E. J. S., Mingels, A. M. A., Thijssen, D. H. J., Passier, R. C. J. J. & Eijsvogels, T. M. H. https://doi.org/10.1249/01.mss.0001054648.81137.2f
 
 
Data of manuscript Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19 (2024) [Dataset Types › Dataset]. 4TU.Centre for Research Data. Weener, H., van Haaps, T., van Helden, R., Albers, H., Haverkate, R., Middelkamp, H., Ridderikhof, M., van Mens, T., van den Berg, A. & Mummery, C. https://doi.org/10.4121/5bb846d8-ed30-4e2e-bfe3-4fb607cbe8ed
 
Multimodal Mapping of Electrical and Mechanical Latency of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Layers (2024) ACS nano, 18(35), 24060-24075. Zhang, X., Burattini, M., Duru, J., Chala, N., Wyssen, N., Cofino Fabres, C., Rivera Arbelaez, J. M., Passier, R., Poulikakos, D., Ferrari, A., Tringides, C., Vörös, J., Battista Luciani, G., Miragoli, M. & Zambelli, T. https://doi.org/10.1021/acsnano.4c03896
 
Standardizing designed and emergent quantitative features in microphysiological systems (2024) Nature Biomedical Engineering, 8, 941-962. Nahon, D., Moerkens, R., Aydogmus, H., Lendemeijer, B., Martínez-Silgado, A., Stein, J., Dostanić, M., Frimat, J.-P., Gontan, C., de Graaf, M. N. S., Hu, M., Kasi, D., Koch, L. S., Le, K., Lim, S., Middelkamp, H. H. T., Mooiweer, J., Montreux-Ragot, P., Niggl, E., … Mummery, C. L. https://doi.org/10.1038/s41551-024-01236-0
 
Global Literature Analysis of Organoid and Organ-on-Chip Research (2024) Advanced healthcare materials, 13(21). Article 2301067. Shoji, J. y., Davis, R. P., Mummery, C. L. & Krauss, S. https://doi.org/10.1002/adhm.202301067
 
The Translational Organ-on-Chip Platform Starter Kit: An ISO-compliant, Reconfigurable Platform for Plug-and-Play Organ-on-Chip Research (2024) [Contribution to conference › Abstract] 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2024. Loessberg-Zahl, J. T., Paul, A., Safai, E., Vollertsen, A. R., Lozeman, J. J. A., Segerink, L., Odijk, M. & van der Meer, A.
 
A Survey of AI Utilisation in High-Throughput Screening Systems Using Stem Cell Models (2024) In Proceedings of the 3rd International Conference on Innovations in Computing Research (ICR’24) (pp. 595-604) (Lecture Notes in Networks and Systems; Vol. 1058 LNNS). Springer. Cao, L., Schwach, V. & Verbeek, F. https://doi.org/10.1007/978-3-031-65522-7_51
 
Micro-Engineered Heart Tissues On-Chip with Heterotypic Cell Composition Display Self-Organization and Improved Cardiac Function (2024) Advanced healthcare materials, 13(18). Article 2303664. Cofiño-Fabres, C., Boonen, T., Rivera-Arbeláez, J. M., Rijpkema, M., Blauw, L., Rensen, P. C. N., Schwach, V., Ribeiro, M. C. & Passier, R. https://doi.org/10.1002/adhm.202303664
 
Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (2024) Advanced materials, 36(28). Article 2308949. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J. https://doi.org/10.1002/adma.202308949
 
Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (Adv. Mater. 28/2024) (2024) Advanced materials, 36(28). Article 2470219. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J. https://doi.org/10.1002/adma.202470219
 
Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells (2024) PLoS ONE, 19(6). Article e0305906. van der Pol, K. H., Koenderink, J., van den Heuvel, J. J. M. W., van den Broek, P., Peters, J., van Bunningen, I. D. W., Pertijs, J., Russel, F. G. M., Koldenhof, J., Morshuis, W. J., van Drongelen, J., Schirris, T. J. J., van der Meer, A. & Rongen, G. A. https://doi.org/10.1371/journal.pone.0305906
 
 
 
A safety screening platform for individualized cardiotoxicity assessment (2024) iScience, 27(3). Article 109139. Schwach, V., Slaats, R. H., Cofiño-Fabres, C., ten Den, S. A., Rivera-Arbeláez, J. M., Dannenberg, M., van Boheemen, C., Ribeiro, M., van der Zanden, S. Y., Nollet, E. E., van der Velden, J., Neefjes, J., Cao, L. & Passier, R. https://doi.org/10.1016/j.isci.2024.109139
 
 
Loss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth (2024) American Journal of Respiratory Cell and Molecular Biology, 70(2), 149-152. Ravi, A., Jia, L., Wu, X., van der Meer, A. D., Gosens, R., Stolk, J., van der Does, A. M., Koning, F., Hiemstra, P. S. & Khedoe, P. P. J. S. https://doi.org/10.1165/rcmb.2023-0084LE
 
 

2023

 
Heart and kidney organoids maintain organ-specific function in a microfluidic system (2023) Materials Today Bio, 23. Article 100818. Gabbin, B., Meraviglia, V., Angenent, M. L., Ward-van Oostwaard, D., Sol, W., Mummery, C. L., Rabelink, T. J., van Meer, B. J., van den Berg, C. W. & Bellin, M. https://doi.org/10.1016/j.mtbio.2023.100818
 
Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules (2023) Nature communications, 14. Article 6685. van Loo, S. R., ten Den, S. A., Araújo-Gomes, N., de Jong, V., Snabel, R., Schot, M. R., Rivera Arbelaez, J. M., Veenstra, G. J., Passier, R., Kamperman, T. & Leijten, J. https://doi.org/10.1038/s41467-023-42297-0
 
The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration (2023) Scientific reports, 13(1). Article 10622. Ortí-Casañ, N., Boerema, A. S., Köpke, K., Ebskamp, A., Keijser, J., Zhang, Y., Chen, T., Dolga, A. M., Broersen, K., Fischer, R., Pfizenmaier, K., Kontermann, R. E. & Eisel, U. L. M. https://doi.org/10.1038/s41598-023-36846-2
 
 
3D Porous Microfluidic Architectures for Heart-on-Chip (2023) [Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023. Paul, A., van Dorp, T., Leferink, A. M., Vollertsen, A. R., van der Meer, A. & Odijk, M.
 
Cell Patterning Technology on Polymethyl Methacrylate through Controlled Physicochemical and Biochemical Functionalization (2023) Biosensors, 13(10). Article 904. Azuaje-Hualde, E., Komen, J., Alonso-Cabrera, J. A., van den Berg, A., de Pancorbo, M. M., van der Meer, A. D., Benito-Lopez, F. & Basabe-Desmonts, L. https://doi.org/10.3390/bios13100904
 
 
 
 
The effect of embedded macrophages on intravascular coagulation in 3D vessels-on-chips (2023) In Abstracts of the 2nd Microphysiological Systems World Summit, Berlin, 2023. Middelkamp, H. H. T., Weener, H. J., Gensheimer, T., Vermeul, K., de Heus, L. E., Albers, H. J., van den Berg, A. & van der Meer, A.
 
Maturing differentiated human pluripotent stem cells in vitro: methods and challenges (2023) Development (Cambridge), 150(11). Article dev201103. Ottaviani, D., ter Huurne, M., Elliott, D. A., Bellin, M. & Mummery, C. L. https://doi.org/10.1242/dev.201103
 
 
 
Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking (2023) Bioengineering and Translational Medicine, 8(3). Article e10513. Rivera-Arbeláez, J. M., Keekstra, D., Cofiño-Fabres, C., Boonen, T., Dostanic, M., ten Den, S. A., Vermeul, K., Mastrangeli, M., van den Berg, A., Segerink, L. I., Ribeiro, M. C., Strisciuglio, N. & Passier, R. https://doi.org/10.1002/btm2.10513
 
Methacrylated human recombinant collagen peptide as a hydrogel for manipulating and monitoring stiffness-related cardiac cell behavior (2023) iScience, 26(4). Article 106423. Mostert, D., Jorba, I., Groenen, B. G. W., Passier, R., Goumans, M. J. T. H., van Boxtel, H. A., Kurniawan, N. A., Bouten, C. V. C. & Klouda, L. https://doi.org/10.1016/j.isci.2023.106423
 
 
 
Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads (2023) Stem cell research, 66. Article 102991. Blanch-Asensio, A., van der Vaart, B., Vinagre, M., Groen, E., Arendzen, C., Freund, C., Geijsen, N., Mummery, C. L. & Davis, R. P. https://doi.org/10.1016/j.scr.2022.102991
 
 
Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip (2023) Lab on a chip, 23(1), 168-181. de Graaf, M. N. S., Vivas, A., Kasi, D. G., van den Hil, F. E., van den Berg, A., van der Meer, A. D., Mummery, C. L. & Orlova, V. V. https://doi.org/10.1039/d2lc00686c
 
 
Segmentation of NKX2.5 Signal in Human Pluripotent Stem Cell-Derived Cardiomyocytes (2023) In Data Science and Artificial Intelligence – 1st International Conference, DSAI 2023, Proceedings (pp. 170-184) (Communications in Computer and Information Science; Vol. 1942 CCIS). Springer. Jongsma, S., Schwach, V., Den, S. A. T., Passier, R., Verbeek, F. J. & Cao, L. https://doi.org/10.1007/978-981-99-7969-1_13
 

2022

Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts (2022) APL Bioengineering, 6(4). Article 046108. Mostert, D., Groenen, B., Klouda, L., Passier, R., Goumans, M. J., Kurniawan, N. A. & Bouten, C. V. C. https://doi.org/10.1063/5.0108914
 
 
Effect of continuous electrical stimulation on engineered 3D cardiac tissues using hPSCs in a versatile platform (2022) [Contribution to conference › Abstract] NanoBioTech-Montreux Conference 2022. Rivera Arbelaez, J. M., Kutucu, C., Snippert, D., Dannenberg, M., Cofino Fabres, C., van den Berg, A., Ribeiro, M., Passier, R. & Segerink, L.
 
Alzheimer’s Disease: Treatment Strategies and Their Limitations (2022) International journal of molecular sciences, 23(22). Article 13954. Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T. & Arab-Tehrany, E. https://doi.org/10.3390/ijms232213954
 
STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells (2022) Cell Reports Methods, 2(10). Article 100300. Blanch-Asensio, A., Grandela, C., Brandão, K. O., de Korte, T., Mei, H., Ariyurek, Y., Yiangou, L., Mol, M. P. H., van Meer, B. J., Kloet, S. L., Mummery, C. L. & Davis, R. P. https://doi.org/10.1016/j.crmeth.2022.100300
 
Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells (2022) Current Protocols, 2(10). Article e564. Bulut, M., Vila Cuenca, M., de Graaf, M., van den Hil, F. E., Mummery, C. L. & Orlova, V. V. https://doi.org/10.1002/cpz1.564
 
 
A Blood-vessel-on-chip to characterize trained immunity in endothelial cells (2022) [Contribution to conference › Poster] EUROoCS Annual Meeting 2022. Le, K., Goosen – Middelkamp, H. H. T., Do, L., Netea, M., Jonkers, I., Orlova, V., Withoff, S., van der Meer, A. & Kumar, V.
 
 
Connecting labs for higher level organ-on-chip systems: integration of a pH sensor and a blood vessel-on-chip on a standardized platform (2022) [Contribution to conference › Paper] EUROoCS Annual Meeting 2022. Vollertsen, A. R., Aydogmus, H., Pollet, A., van Meer, B., van den Berg, A., Mastrangeli, M., Den Toonder, J., Odijk, M. & van der Meer, A.
 
 
Optogenetic Reporters Delivered as mRNA Facilitate Repeatable Action Potential and Calcium Handling Assessment in Human iPSC-Derived Cardiomyocytes (2022) Stem cells, 40(7), 655-668. Yiangou, L., Blanch-Asensio, A., de Korte, T., Miller, D. C., van Meer, B. J., Mol, M. P. H., van den Brink, L., Brandão, K. O., Mummery, C. L. & Davis, R. P. https://doi.org/10.1093/stmcls/sxac029
 
Software Tool for Automatic Quantification of Sarcomere Length and Organization in Fixed and Live 2D and 3D Muscle Cell Cultures In Vitro (2022) Current Protocols, 2(7). Article e462. Stein, J. M., Arslan, U., Franken, M., de Greef, J. C., E. Harding, S., Mohammadi, N., Orlova, V. V., Bellin, M., Mummery, C. L. & van Meer, B. J. https://doi.org/10.1002/cpz1.462
 
Cardiovascular Tissue Engineering and Regeneration: A Plead for Further Knowledge Convergence (2022) Tissue engineering. Part A, 28(11-12), 525-541. Bouten, C. V. C., Cheng, C., Vermue, I. M., Gawlitta, D. & Passier, R. https://doi.org/10.1089/ten.tea.2021.0231
 
Effect of dynamic, intracerebral-like, doxorubicin concentrations on brain stem cancer cells on-chip (2022) [Contribution to conference › Abstract] Microphysiological Systems World Summit, MPS 2022. Komen, J., van den Berg, A., van der Meer, A. & Van Vuurden, D.
 
Toward Human Models of Cardiorenal Syndrome in vitro (2022) Frontiers in Cardiovascular Medicine, 9. Article 889553. Gabbin, B., Meraviglia, V., Mummery, C. L., Rabelink, T. J., van Meer, B. J., van den Berg, C. W. & Bellin, M. https://doi.org/10.3389/fcvm.2022.889553
 
 
 
 
 
 
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation (2022) Nature Biomedical Engineering, 6, 389-402. Harlaar, N., Dekker, S. O., Zhang, J., Snabel, R. R., Veldkamp, M. W., Verkerk, A. O., Fabres, C. C., Schwach, V., Lerink, L. J. S., Rivaud, M. R., Mulder, A. A., Corver, W. E., Goumans, M. J. T. H., Dobrev, D., Klautz, R. J. M., Schalij, M. J., Veenstra, G. J. C., Passier, R., van Brakel, T. J., … de Vries, A. A. F. https://doi.org/10.1038/s41551-021-00827-5
 
 
 
Mechanical constraint model to understand remodeling in beating cardiac microtissues (2022) Biophysical journal, 121(3), 263A-264A. Mostert, D., Masdeu, I. J., Passier, R. P. C. J. J., Kurniawan, N. A. & Bouten, C. V. C. https://doi.org/10.1016/j.bpj.2021.11.1413
 
A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues (2022) Journal of Personalized Medicine, 12(2). Article 214. Ribeiro, M. C., Rivera-Arbelaez, J. M., Cofino-Fabres, C., Schwach, V., Slaats, R. H., ten Den, S. A., Vermeul, K., van den Berg, A., Perez-Pomares, J. M., Segerink, L. I., Guadix, J. A. & Passier, R. https://doi.org/10.3390/jpm12020214
 
Engineering Organoids for in vitro Modeling of Phenylketonuria (2022) Frontiers in Molecular Neuroscience, 14. Article 787242. Borges, A. C., Broersen, K., Leandro, P. & Fernandes, T. G. https://doi.org/10.3389/fnmol.2021.787242
 
A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis (2022) Materials Today Bio, 13. Article 100219. Conceição, F., Sousa, D. M., Loessberg-Zahl, J., Vollertsen, A. R., Neto, E., Søe, K., Paredes, J., Leferink, A. & Lamghari, M. https://doi.org/10.1016/j.mtbio.2022.100219
 
From oral formulations to drug-eluting implants: Using 3D and 4D printing to develop drug delivery systems and personalized medicine (2022) Bio-Design and Manufacturing, 5(1), 85-106. Willemen, N. G. A., Morsink, M. A. J., Veerman, D., Da Silva, C. F., Cardoso, J. C., Souto, E. B. & Severino, P. https://doi.org/10.1007/s42242-021-00157-0
 

2021

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases (2021) Cardiovascular Research, 117(14), 2742-2754. Paloschi, V., Sabater-Lleal, M., Middelkamp, H., Vivas, A., Johansson, S., van der Meer, A., Tenje, M. & Maegdefessel, L. https://doi.org/10.1093/cvr/cvab088
 
 
 
Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro (2021) Haematologica, 106(11). Hoefer, T., Rana, A., Niego, B., Jagdale, S., Albers, H. J., Gardiner, E. E., Andrews, R. K., Van der Meer, A. D., Hagemeyer, C. E. & Westein, E. https://doi.org/10.3324/haematol.2020.250761
 
Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems (2021) Lab on a chip, 21(20), 3963-3978. Schneider, S., Bubeck, M., Rogal, J., Weener, H. J., Rojas, C., Weiss, M., Heymann, M., van der Meer, A. D. & Loskill, P. https://doi.org/10.1039/d1lc00494h
 
 
 
3D Blood Vessels-on-Chip for atherosclerosis modelling (2021) In 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10-14 October 2021, Palm Springs, CA, USA (pp. 16931694) (MicroTAS 2021 – 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Middelkamp, H. H. T., van den Berg, A. & van der Meer, A. D.
 
Automated medium recirculation using macro valves for high flow rates in an endothelial cell culture chip (2021) In 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10-14 October 2021, Palm Springs, CA, USA (pp. 1269-1270). Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L., van der Meer, A. & Odijk, M.
 
Local deposition of nanoparticles on a PDMS Microfluidic device (2021) In 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10-14 October 2021, Palm Springs, CA, USA (pp. 1381-1382). Broccoli, A., Vollertsen, A. R., Roels, P., van Vugt, A., van den Berg, A. & Odijk, M.
 
Multiplexed Organ-on-Chips with integrated macro valves for automated cell culture (2021) In 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 (pp. 1385-1386). Bossink, E. G. B. M., Vollertsen, A. R., Hagen , L. P., van der Meer, A., Segerink, L. & Odijk, M.
 
Cyclic exposure to compressive forces increases the differentiation efficiency of hipscs towards chondrocytes in a cartilage-on-chip platform (2021) [Contribution to conference › Poster] 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021. van Dorp, T., Paggi, C. A., Slaats, R. H., Schwach, V., le Gac, S., Passier, R. & Karperien, M.
 
Cyclic exposure to compressive forces increases the differentiation efficiency of hipscs towards chondrocytes in a cartilage-on-chip platform (2021) In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 495-496). van Dorp, T., Paggi, C. A., Slaats, R. H., Schwach, V., le Gac, S., Passier, R. & Karperien, M.
 
 
 
Engineered models of the human heart: directions and challenges (2021) Stem cell reports, 16(9), 2049-2057. Stein, J. M., Mummery, C. L. & Bellin, M. https://doi.org/10.1016/j.stemcr.2020.11.013
 
Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions (2021) Cells, 10(8). Article 1998. Coenen, D. M., Heinzmann, A. C. A., Oggero, S., Albers, H. J., Nagy, M., Hagué, P., Kuijpers, M. J. E., Vanderwinden, J. M., van der Meer, A. D., Perretti, M., Koenen, R. R. & Cosemans, J. M. E. M. https://doi.org/10.3390/cells10081998
 
Collagen I based enzymatically degradable membranes for organ-on-a-chip barrier models (2021) ACS biomaterials science & engineering, 7(7), 2998-3005. Arik, Y. B., De sa Vivas, A., Laarveld, D., Van Laar, N., Gemser, J., Visscher, T., van den Berg, A., Passier, R. & van der Meer, A. D. https://doi.org/10.1021/acsbiomaterials.0c00297
 
Dynamic inflammatory stimulation of hiPSC-endothelial cells in a multiplexed microfluidic chip (2021) [Contribution to conference › Paper] EUROoCS Annual conference 2021. Vollertsen, A. R., Le, K., van den Hil, L., Vermeul, K., van Meer, B., van den Berg, A., Orlova, V. V., Kumar, V., Odijk, M. & van der Meer, A.
 
 
Organs-on-chips: into the next decade (2021) Nature Reviews Drug Discovery, 20(5), 345-361. Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P. & Tagle, D. A. https://doi.org/10.1038/s41573-020-0079-3
 
 
 
Monitoring contractile cardiomyocytes via impedance using multipurpose thin film ruthenium oxide electrodes (2021) Sensors (Switzerland), 21(4). Article 1433. Tanumihardja, E., de Bruijn, D. S., Slaats, R. H., Olthuis, W. & van den Berg, A. https://doi.org/10.3390/s21041433
 
 
Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips (2021) Scientific reports, 11(1). Article 2281. Middelkamp, H. H. T., Verboven, A. H. A., de Sá Vivas, A. G., Schoenmaker, C., Klein Gunnewiek, T. M., Passier, R., Albers, C. A., ‘t Hoen, P. A. C., Nadif Kasri, N. & van der Meer, A. D. https://doi.org/10.1038/s41598-021-81933-x
 
Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation (2021) Chemico-Biological Interactions, 334. Article 109300. Marasco, D., Vicidomini, C., Krupa, P., Cioffi, F., Huy, P. D. Q., Li, M. S., Florio, D., Broersen, K., De Pandis, M. F. & Roviello, G. N. https://doi.org/10.1016/j.cbi.2020.109300
 
 
A versatile platform that allows mechanical and electrical stimulation to improve maturation of hPSC-derived 3D engineered heart tissues (2021) [Contribution to conference › Poster] NanoBioTech-Montreux 2021. Rivera Arbelaez, J. M., Cofino Fabres, C., Boonen, T. M. P. M., Schwach, V., van den Berg, A., Segerink, L., Ribeiro, M. & Passier, R.
 
Benchmarking the developmental stage of hPSCCMs upon stimulated maturation using a platform for 3D engineered heart tissues (2021) [Contribution to conference › Poster] EUROoCS Annual conference 2021. Cofino Fabres, C., Snabel, R., Rivera Arbelaez, J. M., Boonen, T. M. P. M., Ribeiro, M., Schwach, V., Veenstra, G. J. & Passier, R.
 
Comparing on-chip colorectal cancer spheroid drug response to xenografts (2021) [Contribution to conference › Poster] EUROoCS Annual conference 2021. Komen, J., Bossink, E. G. B. M., van den Berg, A. & van der Meer, A.
 
 
Engineering 3D vascularized heart tissues using hPSC derived cardiac cells (2021) [Contribution to conference › Poster] 11th World Congress on Alternatives and Animal Use in the Life Sciences 2021. Rivera Arbelaez, J. M., Ribeiro, M., Cofino Fabres, C., Schwach, V., Stein, J. M., Mummery, C. L., van den Berg, A., Segerink, L. & Passier, R.
 
ForceTracker: A versatile tool for contractile force assessment in 3D Organ-on-Chip platforms (2021) [Contribution to conference › Poster] EUROoCS Annual conference 2021. Rivera Arbelaez, J. M., Dostanic, M., Stein, J. M., van den Berg, A., Segerink, L. I., Mummery, C. L., Sarro, P. M., Mastrangeli, M., Ribeiro, M. C. & Passier, R.
 
Modeling cardiotoxicity utilizing human pluripotent stem cell-derived cardiomyocytes: towards protective therapy for the heart (2021) [Contribution to conference › Poster] EUROoCS Annual conference 2021. Schwach, V., Slaats, R. H., Cofino Fabres, C., ten Den, S. A., Rivera Arbelaez, J. M., Ribeiro, M., Cao, L. & Passier, R.
 

2020

 
 
New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment (2020) Alternatives to Animal Experimentation, 37(4), 607-622. Punt, A., Bouwmeester, H., Blaauboer, B. J., Coecke, S., Hakkert, B., Hendriks, D. F. G., Jennings, P., Kramer, N. I., Neuhoff, S., Masereeuw, R., Paini, A., Peijnenburg, A. A. C. M., Rooseboom, M., Shuler, M. L., Sorrell, I., Spee, B., Strikwold, M., Van der Meer, A. D., Van der Zande, M., … Heringa, M. B. https://doi.org/10.14573/altex.2003242
 
A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties (2020) Journal of microelectromechanical systems, 29(5), 881-887. Article 9152964. Dostanić, M., Windt, L. M., Stein, J. M., Van Meer, B. J., Bellin, M., Orlova, V., Mastrangeli, M., Mummery, C. L. & Sarro, P. M. https://doi.org/10.1109/JMEMS.2020.3011196
 
A modular microfluidic parallel dispensing system (2020) [Contribution to conference › Abstract] 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020. de Boer, D., Vollertsen, A. R., van den Berg, A., van der Meer, A. & Odijk, M.
 
 
 
 
Multiplexed blood-brain barrier organ-on-chip (2020) Lab on a chip, 20(17), 3132-3143. Zakharova, M., Palma do Carmo, M. A., van der Helm, M. W., Le-The, H., de Graaf, M. N. S., Orlova, V., van den Berg, A., van der Meer, A. D., Broersen, K. & Segerink, L. I. https://doi.org/10.1039/d0lc00399a
 
 
Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes (2020) Toxicological Sciences, 176(1), 103-123. Saleem, U., Meer, B. J. V., Katili, P. A., Yusof, N. A. N. M., Mannhardt, I., Krotenberg Garcia, A., Tertoolen, L., Korte, T. D., Vlaming, M. L. H., McGlynn, K., Nebel, J., Bahinski, A., Harris, K., Rossman, E., Xu, X., Burton, F. L., Smith, G. L., Clements, P., Mummery, C. L., … Denning, C. https://doi.org/10.1093/toxsci/kfaa058
 
 
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease (2020) Cell stem cell, 26(6), 862-879.e11. Giacomelli, E., Meraviglia, V., Campostrini, G., Cochrane, A., Cao, X., van Helden, R. W. J., Krotenberg Garcia, A., Mircea, M., Kostidis, S., Davis, R. P., van Meer, B. J., Jost, C. R., Koster, A. J., Mei, H., Míguez, D. G., Mulder, A. A., Ledesma-Terrón, M., Pompilio, G., Sala, L., … Mummery, C. L. https://doi.org/10.1016/j.stem.2020.05.004
 
In vitro microfluidic disease model to study whole blood-endothelial interactions and blood clot dynamics in real-time (2020) Journal of visualized experiments, 159. Article e61068. Manz, X. D., Albers, H. J., Symersky, P., Aman, J., van der Meer, A. D., Bogaard, H. J. & Szulcek, R. https://doi.org/10.3791/61068
 
 
 
 
Expandable human cardiovascular progenitors from stem cells for regenerating mouse heart after myocardial infarction (2020) Cardiovascular Research, 116(3), 545-553. Schwach, V., Gomes Fernandes, M., Maas, S., Gerhardt, S., Tsonaka, R., Van Der Weerd, L., Passier, R., Mummery, C. L., Birket, M. J. & Salvatori, D. C. F. https://doi.org/10.1093/cvr/cvz181
 
Generation and Functional Characterization of Monocytes and Macrophages Derived from Human Induced Pluripotent Stem Cells (2020) Current Protocols in Stem Cell Biology, 52(1). Article e108. Cao, X., van den Hil, F. E., Mummery, C. L. & Orlova, V. V. https://doi.org/10.1002/cpsc.108
 
Development of double porous poly (ε-caprolactone)/chitosan polymer as tissue engineering scaffold (2020) Materials Science and Engineering C: Materials for Biological Applications, 107. Article 110257. Das, P., Remigy, J. C., Lahitte, J. F., van der Meer, A. D., Garmy-Susini, B., Coetsier, C., Desclaux, S. & Bacchin, P. https://doi.org/10.1016/j.msec.2019.110257
 
Detection of amyloid aggregation in living systems (2020) In Protein Homeostasis Diseases: Mechanisms and Novel Therapies (pp. 127-152). Elsevier. Broersen, K.https://doi.org/10.1016/B978-0-12-819132-3.00007-5
 
Highly parallelized human embryonic stem cell differentiation in nanoliter chambers (2020) In MicroTAS 2020 – 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 861-862). The Chemical and Biological Microsystems Society. Vollertsen, A. R., ten Den, S. A., Schwach, V., van den Berg, A., Passier, R., van der Meer, A. D. & Odijk, M.
 
Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board (2020) Microsystems & nanoengineering, 6(1). Article 107. Vollertsen, A. R., de Boer, D., Dekker, S., Wesselink, B. A. M., Haverkate, R., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., Passier, R., van den Berg, A., van der Meer, A. D. & Odijk, M. https://doi.org/10.1038/s41378-020-00216-z
 
Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis (2020) In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1070-1071). The Chemical and Biological Microsystems Society. Albers, H. J., Linssen, J. E. A., Costa, P. F., Middelkamp, H. H. T., van der Hout, L., Malda, J., Passier, R., van den Berg, A. & van der Meer, A. D.
 

2019

 
Tunable microstructured membranes in organs-on-chips to monitor transendothelial hydraulic resistance (2019) Tissue engineering. Part A, 25(23-24), 1635-1645. Das, P., van der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., Lammertink, R. G. H. & Bacchin, P. https://doi.org/10.1089/ten.tea.2019.0021
 
 
Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusion (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019 (pp. 1530-1531). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D., van den Berg, A., van der Meer, A. & Eijkel, J. C. T.
 
A microfluidic device for testing static and dynamic, in vivo like, drug concentration effects on cancer cells (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Komen, J., Westerbeek, E. Y., van der Meer, A. & van den Berg, A.
 
Standardized, modular microfluidic building blocks for automated cell culturing systems (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 86-87). The Chemical and Biological Microsystems Society. Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., Segerink, L., van der Meer, A. & Odijk, M.
 
Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V (2019) Protein engineering design and selection, 32(10), 443-457. Claes, F., Rudyak, S., Laird, A. S., Louros, N., Beerten, J., Debulpaep, M., Michiels, E., van der Kant, R., Van Durme, J., De Baets, G., Houben, B., Ramakers, M., Yuan, K., Gwee, S. S. L., Hernandez, S., Broersen, K., Oliveberg, M., Moahamed, B., Kirstein, J., … Schymkowitz, J. https://doi.org/10.1093/protein/gzaa008
 
Organs-on-Chips: a new paradigm for safety assessment of drug-induced thrombosis (2019) Current Opinion in Toxicology, 17, 1-8. Ng, P., Belgur, C., Barthakur, S., van der Meer, A. D., Hamilton, G. A. & Barrile, R. https://doi.org/10.1016/j.cotox.2019.08.004
 
Hybrid polyester-hydrogel electrospun scaffolds for tissue engineering applications (2019) Frontiers in bioengineering and biotechnology, 7(SEP). Article 231. de Pinho, A. R. G., Odila, I., Leferink, A., van Blitterswijk, C., Camarero-Espinosa, S. & Moroni, L. https://doi.org/10.3389/fbioe.2019.00231
 
Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes (2019) Nature communications, 10(1). Article 4325. van Meer, B. J., Krotenberg, A., Sala, L., Davis, R. P., Eschenhagen, T., Denning, C., Tertoolen, L. G. J. & Mummery, C. L. https://doi.org/10.1038/s41467-019-12354-8
 
A platform for assessing pro- and anti-arrhythmic effects of drugs based on isogenic human iPSC-derived cardiomyocytes (2019) Acta physiologica, 227(S718), 159-160. Article e13366. Campostrini, G., Sala, L., Ward-van Oostwaard, D., van Meer, B. J., Tertoolen, L. G. J., Bartulos-Encinas, O., Braam, S. R., IJzerman, A. P., Mummery, C. L. & Bellin, M. https://doi.org/10.1111/apha.13366
 
 
 
Scalable microphysiological system to model three-dimensional blood vessels (2019) APL Bioengineering, 3(2). Article 026105. de Graf, M. N. S., Cochrane, A., van den Hil, F. E., Buijsman, W., van der Meer, A., van den Berg, A., Mummery, C. L. & Orlova, V. V. https://doi.org/10.1063/1.5090986
 
 
 
Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy (2019) Lab on a chip, 19(3), 452-463. van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I. https://doi.org/10.1039/c8lc00129d
 
 
 
 
Assessing barrier properties using impedance spectroscopy in a semi-circular, blood-brain barrier on-chip (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 422-423) (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019). The Chemical and Biological Microsystems Society. Avgidis, F., Tibbe, M., Leferink, A. & Segerink, L.
 
Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 432-433). The Chemical and Biological Microsystems Society. Zakharova, M., van der Helm, M., do Carmo, M. P., Le-The, H., Tibbe, M., van der Meer, A., Broersen, K., Eijkel, J. & Segerink, L.
 
Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function (2019) [Contribution to conference › Poster] 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019. Zakharova, M., van der Helm, M., Palma Do Carmo, M., Le The, H., Tibbe, M., van der Meer, A., Broersen, K., Eijkel, J. & Segerink, L.
 
 

2018

 
Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems (2018) Clinical pharmacology & therapeutics, 104(6), 1240-1248. Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A. https://doi.org/10.1002/cpt.1054
 
Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices (2018) In MicroTAS 2018: The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2239-2241). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J., van der Meer, A. D., van den Berg, A. & Eijkel, J. C. T.
 
Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices (2018) In MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2392-2393). The Chemical and Biological Microsystems Society. Albers, H. J., da Silva Simão, J. P., Middelkamp, H. H. T., Mummery, C. L., Passier, R., van den Berg, A., Orlova, V. V. & van der Meer, A. D.
 
Standardized, Modular Parallelization Platform for Microfluidic Large-Scale Integration Cell Culturing Chips (2018) In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2199-2201). The Chemical and Biological Microsystems Society. Vollertsen, A. R., Dekker, S., Wesselink, B. A. M., Haverkate, R., Bomer, J. G., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., van der Meer, A., Passier, R., van den Berg, A. & Odijk, M.
 
Microfluidic assay for the assessment of leukocyte adhesion to human induced pluripotent stem cell-derived endothelial cells (HiPSC-ECs) (2018) Journal of visualized experiments, 2018(141). Article e58678. Halaidych, O. V., van den Hil, F., Mummery, C. L. & Orlova, V. V. https://doi.org/10.3791/58678
 
Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts (2018) Current Protocols in Human Genetics, 99(1). Article e67. van Meer, B. J., Sala, L., Tertoolen, L. G. J., Smith, G. L., Burton, F. L. & Mummery, C. L. https://doi.org/10.1002/cphg.67
 
Differentiation and validation of human iPSC-derived atrial cardiomyocytes (2018) Journal of Pharmacological and Toxicological Methods, 93, 168-168. Article 176. Sutton, K., El Haou, S., Williams, S., Devalla, H., Stoelzle-Feix, S., Juhasz, K., Doerr, L., Beckler, M., Haarmann, C., George, M., Passier, R., Fertig, N. & Rogers, M. https://doi.org/10.1016/j.vascn.2018.01.544
 
Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips (2018) Scientific reports, 8(1). Article 13524. Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M. https://doi.org/10.1038/s41598-018-31912-6
 
 
Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems (2018) Alternatives to Animal Experimentation, 35(3), 353-378. Pamies, D., Bal-Price, A., Chesne, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M. https://doi.org/10.14573/altex.1710081
 
 
Reaktive Sauerstoffspezies und Gefäßdegeneration (2018) Zeitschrift fur Herz-, Thorax- und Gefasschirurgie, 32(3), 242-247. Minol, J. P., Reinsch, I., Luik, M., Leferink, A., Barth, M., Assmann, A., Lichtenberg, A. & Akhyari, P. https://doi.org/10.1007/s00398-018-0227-9
 
 
A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly (2018) In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (pp. 318-321) (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). IEEE. Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., Bouten, C. V. C., Van Den Berg, A., Dekker, R. & Sarro, P. M. https://doi.org/10.1109/MEMSYS.2018.8346550
 
 
 
Musclemotion: A versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo (2018) Circulation research, 122(3), e5-e16. Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., … Mummery, C. L. https://doi.org/10.1161/CIRCRESAHA.117.312067
 
Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics (2018) Clinical pharmacology & therapeutics, 103(2), 332-340. Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E. https://doi.org/10.1002/cpt.742
 
Membranes for Organs-on-Chips (2018) In Biomedical Membranes and (Bio)Artificial Organs (pp. 295-321). World Scientific. Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D. & Segerink, L. https://doi.org/10.1142/9789813223974_0011
 
Porous sbum-micrometer PDMS membranes as cell culture substrates in a microfludiic chip (2018) [Contribution to conference › Poster] 9th International Conference on Microtechnologies in Medicine and Biology, MMB 2018. Tibbe, M. P., Le The, H., Leferink, A. M., Eijkel, J. C. T. & Segerink, L. I.
 
Transwell integrated porous sub-micrometer PDMS membranes as alternative cell culture platform (2018) [Contribution to conference › Poster] EMBS Micro and Nantechnology in Medicine Conference, MNMC 2018. Tibbe, M., Le The, H., Eijkel, J., van den Berg, A., Leferink, A. & Segerink, L.
 

2017

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes (2017) Stem cell reports, 9(6), 1765-1779. Schwach, V., Verkerk, A. O., Mol, M., Monshouwer-Kloots, J. J., Devalla, H. D., Orlova, V. V., Anastassiadis, K., Mummery, C. L., Davis, R. P. & Passier, R. https://doi.org/10.1016/j.stemcr.2017.10.024
 
Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells (2017) Stem cell reports, 9(6), 1754-1764. Guadix, J. A., Orlova, V. V., Giacomelli, E., Bellin, M., Ribeiro, M. C., Mummery, C. L., Pérez-Pomares, J. M. & Passier, R. https://doi.org/10.1016/j.stemcr.2017.10.023
 
 
 
Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip (2017) In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1114-1115) (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society. van der Helm, M., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., van der Meer, A., Eijkel, J., Ingber, D. E., van den Berg, A. & Segerink, L.
 
A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array (2017) In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1013) (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society. Gümüscü, B., Albers, H. J., van den Berg, A., Eijkel, J. & van der Meer, A. D.
 
Chipholder-integrated 3d-printed pneumatic logic controllers for microfluidic chips (2017) In The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 645) (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS(; Vol. 2017). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J., Vollenbroek, J., van der Meer, A., Eijkel, J. & van den Berg, A.
 
 
Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes (2017) Cellular and Molecular Life Sciences, 74(20), 3711-3739. Giacomelli, E., Mummery, C. L. & Bellin, M. https://doi.org/10.1007/s00018-017-2546-5
 
Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs) (2017) Journal of visualized experiments, 2017(123). Article e55587. Sala, L., Ward-van Oostwaard, D., Tertoolen, L. G. J., Mummery, C. L. & Bellin, M. https://doi.org/10.3791/55587
 
A multiplexed organ-on-chip device with individually addressable channels (2017) [Contribution to conference › Poster] 2nd International Organ-on-Chip Symposium, IOOCS17, 2017. Palma Do Carmo, M., van der Helm, M. W., van der Meer, A., van den Berg, A., Eijkel, J. C. T. & Segerink, L.
 
Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation (2017) Journal of thrombosis and haemostasis, 15(5), 972-982. Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E. https://doi.org/10.1111/jth.13666
 
Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells (2017) Development (Cambridge), 144(6), 1008-1017. Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Orlova, V. V. & Mummery, C. L. https://doi.org/10.1242/dev.143438
 
 
Configurable gel geometry via flow patterning for angiogenisis assays (2017) In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1074-1075) (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J., Makkinga, D., van der Meer, A., Eijkel, J. & van den Berg, A.
 
 
Human Ventricular Stem Cell Cardiomyocytes: Validating In Vitro Assays and Screening Platforms for Pro-arrhythmia Risk Prediction (2017) Journal of Pharmacological and Toxicological Methods, 88(2), 241-241. Article 0237. Rogers, M., Ridley, J., El-Haou, S., Williams, S., Webdale, L., Sutton, K., Stoelzle-Feix, S., Thomas, U., Fertig, N., Zwetsloot, T., Devalla, H. D. & Passier, R. https://doi.org/10.1016/j.vascn.2017.09.238
 
InPulse CrackIT Challenge: Development of An In Vitro Platform Using Physiologically Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Screen for Drug-Induced Effects on Cardiac Contractility (2017) Journal of Pharmacological and Toxicological Methods, 88(2), 238-238. Article 0227. Harris, K., Rossman, E., Xu, X., Clements, P., Mannhardt, I., Hansen, A., Saleem, U., Eschenhagen, T., Hortigon, M., Rodriguez, V. Z., Smith, G., van Meer, B., Tertoolen, L., Mummery, C., Catarino Ribeiro, M., Passier, R., de Korte, T., Vlaming, M., Braam, S., … Denning, C. https://doi.org/10.1016/j.vascn.2017.09.228
 
 
Small molecule absorption by PDMS in the context of drug response bioassays (2017) Biochemical and biophysical research communications, 482(2), 323-328. van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P. & Mummery, C. L. https://doi.org/10.1016/j.bbrc.2016.11.062
 

2016

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT (2016) EMBO molecular medicine, 8(12), 1390-1408. Devalla, H. D., Gélinas, R., Aburawi, E. H., Beqqali, A., Goyette, P., Freund, C., Chaix, M. A., Tadros, R., Jiang, H., Le Béchec, A., Monshouwer-Kloots, J. J., Zwetsloot, T., Kosmidis, G., Latour, F., Alikashani, A., Hoekstra, M., Schlaepfer, J., Mummery, C. L., Stevenson, B., … Passier, R. https://doi.org/10.15252/emmm.201505719
 
 
Challenges of immaturity and proliferation in using hPSC-derived cardiomyocytes as disease models (2016) Human Gene Therapy, 27(11), A11-A11. Article INV38. Mummery, C., Birket, M., van Meer, B., Ribeiro, M., Passier, R., Bellin, M., Orlova, V., Davis, G. R., Freund, C., Kosmidis, G. & Tertoolen, L. https://doi.org/10.1089/hum.2016.29035.abstracts
 
 
Go with the flow: humane stamcellen in vasculair onderzoek (2016) [Book/Report › Inaugural speech]. University of Twente. Mummery, C. L.
 
Waar het hart vol van is (2016) [Book/Report › Inaugural speech]. University of Twente. Passier, P. C. J. J.
 
 
 
Ultra-thin nanochannel-based liquid TEM cell for EELS analysis and high resolution imaging (2016) In 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 804-807). IEEE. Arik, Y. B., Matsui, R., Sarajlic, E., Takayama, Y., Boom, B. A., Berenschot, J. W., le Gac, S., Tas, N. R. & Fujita, H. https://doi.org/10.1109/MEMSYS.2016.7421751
 
 
Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium (2016) Biomedical microdevices, 18(73), 73-. Article 73. Jain, A., van der Meer, A. D., Papa, A.-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E. https://doi.org/10.1007/s10544-016-0095-6
 
 
 
 
Stamcellen. Wetenschap, werkelijkheid en fictie (2016) [Book/Report › Book]. Stichting Bio-Wetenschappen en Maatschappij. Karperien, H. B. J. & Mummery, C. L. http://www.biomaatschappij.nl/product/stamcellen-2/
 
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes (2016) European heart journal, 38(4), 292–301. Chen, Z., Xian, W., Bellin, M., Dorn, T., Tian, Q., Goedel, A., Dreizehnter, L., Schneider, C. M., Ward-van Oostwaard, D., Ng, J. K. M., Hinkel, R., Pane, L. S., Mummery, C. L., Lipp, P., Moretti, A., Laugwitz, K.-L. & Sinnecker, D. https://doi.org/10.1093/eurheartj/ehw189
 

2015

 
Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure (2015) Biochemical and biophysical research communications, 467(4), 998-1005. Kosmidis, G., Bellin, M., Ribeiro, M. C., van Meer, B., Ward-van Oostwaard, D., Passier, R., Tertoolen, L. G. J., Mummery, C. L. & Casini, S. https://doi.org/10.1016/j.bbrc.2015.10.026
 
 
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells (2015) Science, 347(6225), 1010-1014. Arner, E., Daub, C. O., Vitting-Seerup, K., Andersson, R., Lilje, B., Drabløs, F., Lennartsson, A., Rönnerblad, M., Hrydziuszko, O., Vitezic, M., Freeman, T. C., Alhendi, A. M. N., Arner, P., Axton, R., Baillie, J. K., Beckhouse, A., Bodega, B., Briggs, J., Brombacher, F., … Passier, R. https://doi.org/10.1126/science.1259418
 
Studying the blood-brain barrier on a microfluidic chip (2015) [Contribution to conference › Paper] In Vitro Toxicology Society Annual Meeting. McKim, J. M., van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I. https://doi.org/10.1089/aivt.2015.29000.abstracts